Premium High-Purity Isoflavone for Nutraceutical, Pharmaceutical & Functional Food Applications
As a specialized supplier of high-value botanical actives, we offer Pharmaceutical-Grade Genistein Powder (≥98% purity) - the most biologically active isoflavone derived from Sophora japonica and soybean sources. With over 2,000 published studies and ongoing clinical trials investigating its therapeutic potential, genistein represents a scientifically validated ingredient for manufacturers targeting women's health, cardiovascular support, cognitive wellness, and metabolic health formulations worldwide.
Scientific Foundation & Molecular Excellence
Genistein (CAS: 446-72-0; molecular formula C₁₅H₁₀O₅) is a naturally occurring isoflavone classified as a phytoestrogen due to its structural similarity to estradiol-17β . This unique molecular architecture enables selective binding to estrogen receptors and modulation of multiple cellular signaling pathways.
Core Identifiers:
| Parameter | Specification |
|---|---|
| IUPAC Name | 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one |
| Molecular Weight | 270.24 g/mol |
| Melting Point | 297-298°C |
| Synonyms | 4',5,7-Trihydroxyisoflavone, Sophoricol, Prunetol |
| CAS Number | 446-72-0 |
Physical Properties:
Appearance: Off-white to yellow crystalline powder
Solubility: Soluble in DMSO, ethanol, DMF; virtually insoluble in water
Storage: −20°C recommended for long-term stability
Clinically Validated Mechanisms of Action
Multi-Target Therapeutic Profile
Genistein's therapeutic versatility stems from its ability to interact with multiple molecular targets:
| Mechanism | Biological Activity | Clinical Relevance |
|---|---|---|
| Estrogen Receptor-β Agonism | Selective binding to ER-β with weak estrogenic activity | Menopause support, bone health |
| Tyrosine Kinase Inhibition | Competitive inhibitor of ATP in protein kinase reactions | Antiangiogenic, anticancer properties |
| Topoisomerase II Inhibition | Interferes with DNA replication in rapidly dividing cells | Chemopreventive potential |
| Antioxidant Activity | Scavenges free radicals, activates Nrf2 pathway | Cellular protection, anti-aging |
| Anti-Inflammatory Modulation | Reduces pro-inflammatory cytokines | Cardiovascular, metabolic support |
| Autophagy/mTOR Pathway Modulation | Regulates cellular cleanup mechanisms | Neuroprotection |
Primary Health Benefits
1. Women's Health & Menopause Support
Genistein's selective estrogen receptor-β binding provides targeted support for menopausal symptoms without the proliferative effects on breast and uterine tissue associated with conventional hormone therapy.
2. Cardiovascular & Metabolic Health
An ongoing clinical trial at National Taiwan University Hospital is evaluating genistein's effects on post-myocardial infarction patients, specifically investigating lipid-lowering and anti-inflammatory properties . The trial uses a dosage of 250 mg twice daily for 3 months.
3. Cognitive Health & Neuroprotection
The GENIAL clinical trial demonstrated that 120 mg/day genistein supplementation for 12 months significantly improved cognitive function in prodromal Alzheimer's disease patients, with treated patients showing no increase in amyloid-β deposition compared to placebo.
4. Bone Health
Genistein has been studied for its potential to prevent postmenopausal osteoporosis through its estrogenic effects on bone metabolism.
5. Cancer Chemoprevention
Research indicates genistein induces apoptosis, inhibits angiogenesis, and arrests cell cycle progression in tumor cells.
Technical Specifications & Quality Assurance
Product Specifications (≥98% Purity)
| Parameter | Specification | Test Method |
|---|---|---|
| Purity (Genistein) | ≥98% - 99.5% (HPLC) | HPLC-UV |
| Appearance | White to off-white fine powder | Visual |
| Particle Size | 80-120 mesh (customizable) | Sieve analysis |
| Loss on Drying | ≤3.0% | Gravimetric |
| Heavy Metals (Total) | ≤10 ppm | ICP-MS |
| Lead (Pb) | ≤1.0 ppm | ICP-MS |
| Arsenic (As) | ≤1.0 ppm | ICP-MS |
| Cadmium (Cd) | ≤1.0 ppm | ICP-MS |
| Mercury (Hg) | ≤0.05 ppm | ICP-MS |
| Total Plate Count | ≤1,000 CFU/g | ISO 4833 |
| Yeast & Mold | ≤100 CFU/g | ISO 21527 |
| E. coli | Negative | USP <62> |
| Salmonella | Negative | USP <62> |
Available Grades
| Grade | Purity | Applications |
|---|---|---|
| Nutraceutical Grade | 98% | Dietary supplements, functional foods |
| Pharmaceutical Grade | 99% - 99.5% | Clinical research, advanced formulations |
| Reference Standard | ≥98% | Analytical testing, quality control |
Certifications
ISO 9001, GMP Certified Manufacturing
ISO 22000, HACCP Food Safety
Kosher, Halal Certified Options
FDA Registered Facility
Non-GMO, Allergen-Free
Sustainable Extraction & Manufacturing Excellence
Advanced GRAS Solvent Technology
Traditional genistein extraction methods rely on toxic solvents such as methanol and concentrated hydrochloric acid, creating safety concerns and regulatory hurdles.
Our Innovation: We utilize a food-grade extraction method using ethanol and 5N acetic acid - both classified as GRAS (Generally Recognized as Safe) - achieving genistein yields of 75.32 mg per 100 g of raw material . This represents approximately:
15% higher yield than conventional methanol/HCl methods
83% higher yield than ethanol-only extraction
This environmentally sustainable approach eliminates toxic solvent residues and meets the growing demand for clean-label, regulatory-compliant ingredients.
Source Material Options
Sophora japonica (Japanese Pagoda Tree): Highest genistein concentration, preferred for pharmaceutical applications
Non-GMO Soybean Extract: Sustainable alternative for nutraceutical formulations
Quality Control Highlights
Batch-specific Certificates of Analysis (CoA)
Third-party laboratory verification available
Full traceability from raw material to finished product
Stability testing under ICH conditions (24-month shelf life)
Global B2B Applications
Nutraceuticals & Dietary Supplements
| Application | Recommended Dosage | Formulation Synergies |
|---|---|---|
| Women's Health | 50-100 mg/day | Black cohosh, chasteberry, vitamin D3 |
| Cardiovascular Support | 250 mg BID | CoQ10, omega-3, resveratrol |
| Cognitive Health | 120 mg/day | Bacopa, phosphatidylserine, luteolin |
| Bone Health | 50-100 mg/day | Vitamin K2, magnesium, calcium |
| Metabolic Wellness | 100-250 mg/day | Berberine, chromium, cinnamon |
Formats Available:
Capsules and tablets
Powder blends and stick packs
Liquid suspensions (with solubilizers)
Effervescent formulations
Functional Foods & Beverages
| Application | Usage Level | Formulation Considerations |
|---|---|---|
| Fortified Beverages | 0.1-0.5% | Requires solubilization technology |
| Nutritional Bars | 0.2-1.0% | Heat-stable; mask bitterness |
| Dairy Alternatives | 0.1-0.3% | Compatible with plant-based matrices |
| Functional Confectionery | 0.2-0.8% | Encapsulation recommended |
Pharmaceutical Development
Investigational New Drug (IND) Applications: High-purity (≥99.5%) material for clinical trials
Formulation Research: Custom particle sizes and delivery systems
Reference Standards: Certified material for analytical QC
Cosmeceutical Applications
Anti-Aging Serums: 0.5-2.0% for antioxidant protection
Brightening Creams: Tyrosinase inhibition for even skin tone
Hair Care: Scalp health formulations
Bioavailability Enhancement Strategies
Genistein's poor water solubility (8.7 μg/mL) and extensive first-pass metabolism present formulation challenges . We offer multiple enhancement options:
| Technology | Bioavailability Improvement | Applications |
|---|---|---|
| Phytosome® Complex | ↑ 5-10x | Oral supplements, capsules |
| Cyclodextrin Inclusion | ↑ 3-5x | Beverages, liquid formulations |
| Micronization | ↑ 2-3x | Tablets, powder blends |
| Lipid-Based Delivery | ↑ 4-8x | Softgels, functional foods |
| Aglycone Form | Endogenous active form | Maximum bioavailability |
Supplier Selection & Procurement Strategy
Why Source from China
China produces over 80% of the world's genistein powder, with Shaanxi Province accounting for more than 70% of national output . Key advantages include:
Vertically integrated manufacturing from raw material to finished product
Advanced extraction technologies and testing infrastructure
Competitive pricing ($25-45 per kg for ≥98% purity)
Scalable capacity from R&D samples to multi-ton bulk orders
Supplier Evaluation Criteria
| Criterion | What to Look For |
|---|---|
| Manufacturer vs. Trader | Direct manufacturers offer better pricing and quality control |
| Certifications | ISO 9001, GMP, FDA registration, Kosher/Halal |
| Testing Capabilities | In-house HPLC, GC-MS, ICP-MS laboratories |
| Documentation | Batch-specific CoA, stability data, MSDS |
| On-Time Delivery | Target ≥95% delivery reliability |
| Response Time | ≤2 hours for inquiries indicates strong service |
Price Benchmarks (FOB China)
| Supplier Type | Price Range (USD/kg) | MOQ |
|---|---|---|
| Standard 98% | $25-35 | 10-25 kg |
| Premium 99%+ | $35-45 | 5-10 kg |
| Pharmaceutical Grade | $40-55 | 1-5 kg |
Why Partner With Us?
1. Technical Excellence
GRAS-compliant extraction technology for clean-label formulations
Rigorous quality control with third-party verification
Formulation support for bioavailability challenges
2. Regulatory Compliance
Comprehensive documentation for FDA, EFSA, and global markets
Kosher, Halal, and Non-GMO certifications available
Full traceability from raw material to finished product
3. Supply Chain Reliability
Vertically integrated manufacturing in Shaanxi Province
Scalable capacity from R&D to commercial quantities
Temperature-controlled logistics worldwide
4. Customer Partnership
Technical consultation for application development
Custom specifications and private labeling
Dedicated account management
Storage & Handling Guidelines
Store in tightly sealed containers at −20°C for long-term stability
Protect from light, moisture, and strong odors
Use clean, dry utensils to prevent contamination
Shelf life: 24 months when stored properly
Request Samples & Technical Documentation
Advance your formulations with clinically validated genistein powder. Contact our B2B specialists today to:
✓ Request product samples for R&D evaluation
✓ Receive comprehensive technical dossiers
✓ Discuss custom purity and particle size requirements
✓ Obtain competitive bulk pricing
✓ Schedule a technical consultation
Partner with us to deliver science-backed, premium-quality genistein solutions to your customers worldwide.
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