As a specialized B2B supplier of high-purity bioactive ingredients, we offer Pharmaceutical-Grade Fisetin Powder (≥98% purity) - a naturally occurring flavonoid that has emerged as one of the most promising senolytic agents for cellular health, healthy aging, and metabolic wellness. With over a dozen FDA-registered clinical trials investigating its therapeutic potential and a market projected to reach USD 7.09 billion by 2030, fisetin represents a strategic opportunity for manufacturers targeting the rapidly expanding longevity, sports nutrition, and functional food markets worldwide.
What is Fisetin?
Fisetin (CAS 528-48-3; molecular formula C₁₅H₁₀O₆; molecular weight 286.24 g/mol) is a naturally occurring flavonol found in various fruits and vegetables, with the highest concentrations in strawberries (160 µg/g), apples (27 µg/g), persimmons (10.5 µg/g), grapes, onions, and cucumbers. First isolated in 1833, this hydrophobic polyphenolic compound has attracted significant scientific attention due to its potent antioxidant, anti-inflammatory, and senolytic properties.
Unlike many other flavonoids, fisetin demonstrates a unique dual action: it selectively clears senescent ("zombie") cells while simultaneously modulating multiple aging pathways, making it one of the most comprehensively studied natural compounds for healthy aging intervention.
Global Market Overview: A High-Growth Ingredient with Unprecedented Momentum
The fisetin market is experiencing explosive growth across multiple segments, driven by increasing investments in longevity research, growing demand for premium nutraceuticals, and expanding clinical validation.
Market Size & Projections
| Source | 2025 Value | 2026 Projection | 2030/2036 Projection | CAGR |
|---|---|---|---|---|
| Research and Markets | USD 3.8 billion | USD 4.31 billion | USD 7.09 billion (2030) | 13.3% |
| OG Analysis | USD 282.1 million | - | USD 527 million (2034) | 9.4% |
| Future Market Insights | - | USD 308.5 million | USD 757.6 million (2036) | 9.4% |
Note: Market size variations reflect differing definition scopes - Research and Markets encompasses the broader fisetin market including finished products, while OG Analysis and Future Market Insights focus specifically on the fisetin ingredient market.
Key Market Drivers
- Explosive Longevity Research Investment: The global wellness economy expanded from approximately $5.8 trillion in 2022 to $6.3 trillion in 2023, reflecting nearly 9% year-on-year growth, directly supporting the fisetin market.
- Senolytics Segment Growth: The OTC/supplements senolytics segment alone is growing at a CAGR of 8.6%. The broader senolytic fisetin-quercetin market was valued at USD 1.4 billion in 2025 and is expected to reach USD 4.1 billion by 2034 at a CAGR of 12.7%.
- Dietary Supplements Dominance: Supplements are estimated to hold 54.7% market share by application in 2026, supported by repeat production across established supplement formats.
- High-Purity Grade Demand: The ≥98% purity grade is forecast to represent 64.1% of purity-grade demand in 2026.
- Clinical Trial Momentum: Over a dozen FDA-registered clinical trials are investigating fisetin across multiple indications including Alzheimer's disease, peripheral artery disease, cancer survivorship, and COVID-19.
The Science: Understanding Fisetin's Senolytic Mechanism
Primary Mechanism: Selective Senescent Cell Clearance
Fisetin belongs to a class of compounds known as senolytics - agents that selectively eliminate senescent cells that accumulate with age and contribute to chronic inflammation, tissue dysfunction, and age-related diseases.
Key Mechanistic Pathways:
- PI3K-AKT-BCL-2/BCL-XL Pathway Modulation: Fisetin selectively induces apoptosis in senescent cells through inhibition of anti-apoptotic proteins
- SIRT1 Activation: Modulates the mTOR/AMPK energy-sensing axis and activates SIRT1-dependent deacetylase activity
- NF-κB Suppression: Exerts senomorphic effects through suppression of the NF-κB transcription factor and downstream SASP (Senescence-Associated Secretory Phenotype) components
- NLRP3 Inflammasome Inhibition: Reduces secretion of pro-inflammatory cytokines IL-6 and IL-8
The Senolytic Advantage
Fisetin's ability to clear senescent cells is particularly significant because senescent cell accumulation is now recognized as a fundamental driver of aging and age-related diseases. By removing these dysfunctional cells, fisetin helps restore tissue function, reduce chronic inflammation, and support healthy aging.
Clinically Validated Health Benefits (2025–2026 Research)
1. Muscle Health & Sarcopenia Prevention
A landmark 2025 study published in Aging Cell demonstrated that intermittent fisetin supplementation improved physical function and decreased cellular senescence in skeletal muscle with aging. Improvements in frailty and grip strength with fisetin were comparable to those observed with genetic-based clearance of senescent cells.
Ongoing Clinical Trials:
- The TROFFi Trial (NCT05595499), a multicenter randomized phase II trial, is evaluating fisetin (20 mg/kg/day orally on days 1-3 of each 14-day cycle) in 88 frail postmenopausal breast cancer survivors
- The REVITALiSE trial at NIHR Newcastle BRC is investigating fisetin as a potential treatment for sarcopenia, targeting the removal of senescent cells from muscle to improve muscle health and function in later life
2. Cognitive Health & Neuroprotection
A pilot study is currently evaluating the safety and tolerability of fisetin in older adults with mild cognitive impairment or mild Alzheimer's disease dementia. Preclinical research demonstrates that fisetin reduces SASP, enhances glucose and energy metabolism, and improves cognitive performance in aging models.
3. Metabolic Health & Inflammation Resolution
A 2026 randomized controlled trial published in the Journal of the International Society of Sports Nutrition investigated 12 weeks of fisetin supplementation (200 mg/day) combined with interval resistance-aerobic training in 44 obese adult males.
Key Findings:
- Significant improvements in Maresin-1 (a pro-resolving mediator) (p = 0.034)
- Reductions in IL-6 (p = 0.001) and TNF-α (p = 0.001)
- Decreased fasting blood glucose, insulin, and HOMA-IR (p = 0.001)
- Greatest improvements observed in the training-plus-fisetin group, demonstrating synergy between exercise and fisetin's anti-inflammatory properties
4. Cardiovascular Health & Peripheral Artery Disease
The FIRST Trial (NCT06399809) is investigating whether fisetin can reduce senescent cell abundance in blood, skeletal muscle, and adipose tissue, and improve 6-minute walk distance in 34 people with peripheral artery disease. Of three senolytic therapies being tested in clinical trials, fisetin has the best safety profile.
5. Lung Health & Immune Function
A 2026 randomized, double-blind, placebo-controlled pilot trial in 10 adults with CVID-associated GLILD (a chronic lung disease) demonstrated that fisetin (20 mg/kg on days 0-1 and 28-29) was well tolerated with no adverse events and showed benefit in diffusion capacity, lung volumes, and mental health-related outcomes.
6. Cancer Survivorship & Chemotherapy-Induced Aging
The TROFFi Trial represents one of the first aging-guided interventional strategies in oncology to directly target therapy-induced biological aging. Preclinical studies demonstrate that fisetin reduces senescent cell burden, improves mitochondrial function, and restores muscle strength.
7. Skin Health & Photoaging Protection
Recent research has investigated fisetin topical delivery via ascorbyl palmitate/hyaluronan-enhanced formulations to counteract UVB-induced skin photoaging. Studies confirm fisetin's roles in improving skin barrier function and anti-aging effects in epidermal keratinocytes.
Technical Specifications: Pharmaceutical-Grade Standards
Our fisetin powder meets rigorous international quality standards, ensuring batch-to-batch consistency and regulatory readiness for global markets.
Product Specifications (≥98% Purity)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Fisetin (3,3′,4′,7-tetrahydroxyflavone) | - |
| CAS Number | 528-48-3 | - |
| Molecular Formula | C₁₅H₁₀O₆ | - |
| Molecular Weight | 286.24 g/mol | - |
| Appearance | Yellow to brownish-yellow crystalline powder | Visual |
| Purity (HPLC) | ≥98.0% – 99.5% | HPLC |
| Loss on Drying | ≤5.0% – 6.0% | USP <731> |
| Ash Content | ≤5.0% | USP <281> |
| Particle Size | ≥90% through 80 mesh | Sieve analysis |
Heavy Metal Limits
| Metal | Limit | Test Method |
|---|---|---|
| Lead (Pb) | ≤1.0 ppm | AAS / ICP-MS |
| Arsenic (As) | ≤1.0 ppm | AAS / ICP-MS |
| Cadmium (Cd) | ≤0.5 ppm | AAS / ICP-MS |
| Mercury (Hg) | ≤0.1 ppm | AAS / ICP-MS |
Available Grades
| Grade | Purity | Applications |
|---|---|---|
| Standard Nutraceutical | ≥98% | Dietary supplements, capsules, tablets |
| Premium Pharmaceutical | ≥99% – 99.5% | Clinical research, advanced formulations |
| Cosmetic Grade | ≥98% | Skincare, anti-aging formulations |
Certifications & Compliance
- Manufacturing Certifications: cGMP, ISO 9001, ISO 22000, HACCP, FSSC 22000
- Product Certifications: Kosher, Halal, Non-GMO
- Regulatory Status: FDA-registered facility; compliant with dietary supplement regulations
- Third-Party Verification: Batch-specific Certificates of Analysis (CoA) with each shipment
Bioavailability: The Formulation Challenge & Solutions
The Challenge
Fisetin is notoriously poorly absorbed due to its hydrophobic nature and extensive first-pass metabolism. Standard fisetin supplements typically contain 100–500 mg per capsule, but without bioavailability enhancement, much of this remains unabsorbed.
Advanced Delivery Technologies
We offer access to multiple bioavailability enhancement platforms:
| Technology | Bioavailability Improvement | Applications |
|---|---|---|
| Liposomal Encapsulation | Significantly enhanced absorption | Capsules, liquid formulations |
| Fenugreek Fiber Coating | Up to 25x bioavailability enhancement | Capsules, tablets |
| Self-Emulsifying Systems | Improved solubility and absorption | Softgels, liquid formulations |
| Nanoparticle Formulations | Enhanced topical and oral delivery | Skincare, oral supplements |
The clinical trial dosage for fisetin in senolytic applications is typically 20 mg/kg/day for 2–3 consecutive days, with some studies using 200 mg/day for extended periods.
Global B2B Applications Across Industries
1. Nutraceuticals & Dietary Supplements (Largest Segment - 54.7%)
| Application | Recommended Dosage | Formulation Synergies |
|---|---|---|
| Longevity & Healthy Aging | 100–500 mg/day | Pairs with NMN, NR, resveratrol, urolithin A |
| Senolytic Protocols | 20 mg/kg/day (2-3 days) | Intermittent dosing protocols |
| Muscle Health & Sarcopenia | 100–500 mg/day | With protein, creatine, HMB |
| Metabolic Wellness | 100–200 mg/day | With berberine, chromium, cinnamon |
| Cognitive Health | 100–500 mg/day | With Bacopa, Phosphatidylserine, Lion's Mane |
| Inflammation Support | 100–200 mg/day | With curcumin, omega-3 |
Available Formats: Capsules, tablets, powder blends, stick packs, liposomal formulations
2. Functional Foods & Beverages
| Application | Usage Level | Considerations |
|---|---|---|
| Wellness Shots & Elixirs | 1–5% | Bioavailability enhancement recommended |
| Functional Beverages | 0.5–2% | Stability in liquid matrices requires formulation expertise |
| Nutritional Bars & Snacks | 0.5–1.5% | Heat-stable at standard processing temperatures |
3. Cosmetics & Personal Care
| Application | Concentration | Claim Support |
|---|---|---|
| Anti-Aging Serums & Creams | 0.5–2.0% | UVB protection, photoaging prevention |
| Skin Barrier Repair | 0.5–1.5% | Barrier function improvement |
| Protective Skincare | 0.5–1.0% | Antioxidant, anti-inflammatory benefits |
4. Pharmaceutical Development
- Clinical Trial Material: High-purity (≥99%) for IND applications
- Phase II Trial Support: Material for ongoing senolytic research
- Reference Standards: Certified material for analytical quality control
The China Advantage: Strategic Sourcing for B2B Buyers
China has emerged as a dominant force in the fisetin supply chain, with Shaanxi Province serving as the primary hub for extraction and manufacturing.
Key Advantages
- Vertically Integrated Supply Chains: Full control from raw material sourcing (smoke tree/Cotinus coggygria) to finished powder
- Advanced Manufacturing Infrastructure: State-of-the-art extraction and purification facilities with GMP, ISO, and HACCP certifications
- Scale & Capacity: Production capacities enabling reliable supply for global demand
- Competitive Pricing: Direct manufacturer pricing with flexible MOQs starting from 1 kg
- Multiple Purity Grades: ≥98%, ≥99%, and ≥99.5% specifications available
- Innovation Leadership: In August 2024, Bonerge Lifescience announced the initiation of clinical trials for BeFisetin - the first fisetin extract to reach 99% purity
Supplier Evaluation Criteria for B2B Buyers
| Criterion | What to Look For |
|---|---|
| Manufacturer Type | Direct manufacturer (vs. trader) for better pricing and quality control |
| Certifications | cGMP, ISO 9001, HACCP, Kosher, Halal |
| Testing Capabilities | In-house HPLC, ICP-MS laboratories |
| Purity | ≥98% (HPLC verified) |
| Source Material | Smoke tree (Cotinus coggygria) or other verified natural sources |
| Documentation | Batch-specific CoA, stability data, MSDS |
| Supply Chain | Vertically integrated from raw material to finished product |
Storage & Handling Recommendations
| Parameter | Recommendation |
|---|---|
| Storage Temperature | 15–25°C (59–77°F), cool and dry |
| Environment | Protect from moisture, light, and oxygen |
| Packaging | Keep sealed in original packaging; avoid exposure to air |
| Shelf Life | 24 months from date of manufacture in original sealed packaging |
Why Partner With Us?
1. Technical & Formulation Excellence
- Vertically integrated manufacturing: Full control from raw material sourcing to finished powder
- Multiple purity grades: ≥98%, ≥99%, ≥99.5% specifications available
- Bioavailability solutions: Access to liposomal and enhanced-absorption formulations
- Formulation support: Guidance on optimal dosage, blend compatibility, and application-specific challenges
2. Regulatory & Compliance Leadership
- Full documentation: Batch-specific CoA, MSDS, Certificate of Origin, stability data
- Third-party testing: Comprehensive quality control with SGS-audited verification
- Global compliance: Documentation for FDA, EFSA, and other international regulatory bodies
- Clinical trial support: High-purity material for research applications
3. Supply Chain Security
- Scalable production capacity: From R&D samples to full container orders
- Flexible MOQs: Starting from 1 kg
- Reliable delivery schedules: Consistent supply for your manufacturing needs
4. Customer Partnership
- Dedicated account management: Responsive service for B2B partners
- Private labeling and OEM/ODM services: Custom capsule, tablet, and powder sachet filling
- Co-development opportunities: Custom formulations for specific applications
- Competitive tiered pricing: Direct manufacturer pricing with volume discounts
Request Samples & Technical Documentation
Elevate your product lines with pharmaceutical-grade fisetin powder - a scientifically validated, premium senolytic ingredient for the global longevity, sports nutrition, and metabolic health markets. Contact our B2B specialists today to:
✓ Request product samples for R&D evaluation (1 kg MOQ available)
✓ Receive comprehensive technical dossiers (CoA, MSDS, stability data)
✓ Discuss custom purity specifications (≥98%, ≥99%, ≥99.5%)
✓ Explore bioavailability enhancement options (liposomal, enhanced-absorption)
✓ Obtain competitive bulk pricing based on volume
✓ Schedule a technical consultation for formulation support
Partner with us to deliver science-backed, premium-quality fisetin solutions to your customers worldwide.
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