As a specialized B2B supplier of high-purity bioactive ingredients, we offer Pharmaceutical-Grade Urolithin A Powder (≥98% purity) - a gut-derived postbiotic metabolite that has emerged as one of the most clinically validated compounds for mitochondrial health, muscle function, and healthy aging. Produced through advanced fermentation technology that bypasses the variability of individual gut microbiome conversion, our urolithin A powder delivers consistent, reliable potency for manufacturers targeting the rapidly expanding longevity, sports nutrition, and metabolic health markets worldwide.
What is Urolithin A?
Urolithin A (CAS 1143-70-0; molecular formula C₁₃H₈O₄; molecular weight 228.20 g/mol) is a naturally occurring metabolite produced by gut microbiota from ellagitannins - polyphenolic compounds found in pomegranates, berries, and nuts. However, not everyone possesses the specific gut bacteria required to convert ellagitannins into urolithin A; studies suggest that only 30–40% of the population are efficient producers. This inter-individual variability makes direct urolithin A supplementation the only reliable way to ensure consistent exposure to this bioactive compound.
The Science: Urolithin A as a Potent Mitophagy Activator
Primary Mechanism of Action
Urolithin A is best known as a potent inducer of mitophagy - the selective autophagic clearance of damaged mitochondria. By clearing dysfunctional mitochondria and stimulating mitochondrial biogenesis, urolithin A promotes the renewal of healthy mitochondria, a process that naturally declines with age.
Key Mechanistic Pathways:
Restores PINK1/Parkin-mediated mitophagy in neurons
Attenuates neuroinflammation via NF-κB/NLRP3/cGAS-STING pathways
Exerts antioxidant and anti-inflammatory bioactivities
Induces autophagy and apoptosis, inhibits cell cycle progression
Unique Position in the Market
While many compounds demonstrate mitophagy-modulating effects in preclinical studies, urolithin A currently provides the most consistent human evidence, improving mitophagy markers and functional outcomes in randomized trials. This positions it as the leading clinically validated mitophagy activator available for commercial formulations.
Clinically Validated Health Benefits (2025–2026 Research)
1. Muscle Strength & Physical Performance
Clinical trials in middle-aged and older adults have consistently demonstrated that urolithin A supplementation improves muscle strength, endurance, and biomarkers of mitochondrial health. A 2025 randomized, double-blind, placebo-controlled study is currently assessing the effects of urolithin A (Mitopure®) supplementation on muscle strength and performance in healthy middle-aged adults. Emerging research also suggests that urolithin A facilitates recovery by downregulating inflammatory pathways and indirect markers of muscle damage.
2. Immune System Support & Healthy Aging
A landmark 2025 randomized, placebo-controlled trial published in Nature Aging investigated the effect of urolithin A on age-related immune decline. The study builds on previous research demonstrating that urolithin A expands T memory stem cells (TSCM) and naive T cells in mice, suggesting potential for immune resilience and healthy aging support.
3. Cognitive Health & Neuroprotection
A Phase 2 Alzheimer's trial presented at AAIC 2026 is evaluating the effects of urolithin A on mitophagy/autophagy activity, oxidative stress, multi-omic profiling, and cognitive function in APOE4 carriers. Preclinical research demonstrates that urolithin A robustly restores PINK1/Parkin-mediated mitophagy in neurons and effectively attenuates neuroinflammation, providing a strong mechanistic foundation for neuroprotective applications.
4. Cardiovascular Health
2025 findings support urolithin A's role in supporting cardiovascular health, further expanding its application scope beyond muscle and longevity.
5. Running Performance & Recovery in Athletes
A 2025 clinical study is evaluating the impact of urolithin A supplementation on running performance, recovery, and mitochondrial biomarkers in highly trained male distance runners, suggesting potential applications in elite sports nutrition.
Global Market Overview: A Rapidly Expanding Category
The urolithin A market is experiencing robust growth across multiple segments, driven by increasing consumer awareness of mitochondrial health, expanding clinical evidence, and growing demand for science-backed longevity ingredients.
Market Size & Projections
| Market Segment | 2025 Value | 2026 Projection | 2032 Projection | CAGR |
|---|---|---|---|---|
| Total Urolithin A Market | USD 1.14 billion | USD 1.27 billion | USD 2.55 billion | 12.14% |
| Food Grade Urolithin A | USD 113.82 million | USD 130.75 million | USD 292.47 million | 14.43% |
| Urolithin A Supplement Market | USD 532 million | - | USD 889 million | 8.9% |
| Pharmaceutical Grade Urolithin A | USD 351 million | - | USD 631 million | 8.6% |
Key Market Drivers
Expanding Clinical Evidence: Multiple high-quality trials published in 2025–2026 across muscle, immune, cognitive, and cardiovascular health
Aging Global Population: Rising demand for interventions that support healthy longevity and age-related vitality
Sports Nutrition Applications: Growing interest in mitochondrial-targeted performance and recovery ingredients
Regulatory Clarity: FDA GRAS Notice (GRN No. 791) for urolithin A as an ingredient in protein shakes and beverages
Technical Specifications: Pharmaceutical-Grade Standards
Our urolithin A powder meets rigorous international quality standards, ensuring batch-to-batch consistency and regulatory readiness for global markets.
Product Specifications (≥98% Purity)
| Parameter | Specification | Test Method |
|---|---|---|
| Product Name | Urolithin A (3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one) | - |
| CAS Number | 1143-70-0 | - |
| Molecular Formula | C₁₃H₈O₄ | - |
| Molecular Weight | 228.20 g/mol | - |
| Appearance | Pale brown to off-white fine powder | Visual |
| Purity | ≥98% – 99% (HPLC) | HPLC |
| Moisture | ≤5% | USP |
| Ash Content | ≤2% | USP |
| Heavy Metals | ≤10 ppm | ICP-MS |
| Melting Point | 340–345°C | - |
Available Grades
| Grade | Purity | Applications |
|---|---|---|
| Standard Nutraceutical | ≥98% | Dietary supplements, capsules, tablets |
| Premium Pharmaceutical | ≥99% | Clinical research, advanced formulations |
| Food Grade | ≥98% | Functional foods, beverages |
Certifications & Compliance
Manufacturing Certifications: cGMP, ISO 9001, ISO 22000, HACCP
Regulatory Status: FDA GRAS Notice GRN No. 791 for use in protein shakes and beverages
Third-Party Verification: Batch-specific Certificates of Analysis (CoA) with each shipment
Supply Capacity: Up to 1,000 kg
Production Method: Advanced Fermentation Technology
The Challenge of Natural Production
Urolithin A is produced in the gut through microbial metabolism of ellagitannins - compounds found in pomegranates and other fruits. However, individual gut microbiome composition varies significantly, meaning that not everyone can produce urolithin A from dietary sources. This variability makes direct supplementation the only reliable approach.
Our Fermentation-Based Production
We utilize advanced fermentation technology that produces urolithin A through controlled microbial processes, bypassing the variability of individual gut conversion. This approach ensures:
Consistent potency batch after batch
High purity (≥98%–99%)
Scalable production for commercial volumes
Clean, sustainable manufacturing
Global B2B Applications
1. Nutraceuticals & Dietary Supplements
| Application | Recommended Dosage | Formulation Synergies |
|---|---|---|
| Longevity & Healthy Aging | 250–500 mg/day | Pairs with NMN, NR, resveratrol, CoQ10 |
| Muscle Health & Sarcopenia Prevention | 250–500 mg/day | With protein, creatine, HMB |
| Sports Nutrition & Performance | 250–500 mg/day | Pre/post-workout formulations |
| Immune Support Complexes | 250–500 mg/day | With vitamin C, zinc, elderberry |
| Cognitive Health Nootropics | 250–500 mg/day | With Bacopa, Phosphatidylserine, Lion's Mane |
Available Formats: Capsules, tablets, powder blends, stick packs
2. Functional Foods & Beverages
| Application | Usage Level | Considerations |
|---|---|---|
| Protein Shakes | 0.5–2% | FDA GRAS-approved use |
| RTD Beverages | 0.5–1.5% | Stable in ready-to-drink formulations |
| Meal Replacement Beverages | 0.5–2% | Non-milk based formulations |
| Nutritional Bars & Snacks | 0.5–1.5% | Heat-stable at standard processing temperatures |
3. Cosmetics & Personal Care
| Application | Concentration | Claim Support |
|---|---|---|
| Anti-Aging Serums & Creams | 0.5–2.0% | Mitochondrial health, cellular renewal |
| Protective Skincare | 0.5–1.5% | Antioxidant, anti-inflammatory benefits |
4. Pharmaceutical Development
Clinical Trial Material: High-purity (≥99%) for IND applications
Phase 2 Alzheimer's Trial Support: Material for cognitive health research
Reference Standards: Certified material for analytical quality control
Why Source Urolithin A from China?
China is emerging as a leading global producer of urolithin A, offering B2B buyers significant advantages:
Key Advantages
Advanced Fermentation Infrastructure: State-of-the-art fermentation facilities with GMP, ISO, and HACCP certifications
Scale & Capacity: Supply capacities up to 1,000 kg
Competitive Pricing: Direct manufacturer pricing with flexible MOQs (starting from 1 kg)
Multiple Purity Grades: 98%–99% specifications available
FDA GRAS Compliance: Production aligned with FDA GRAS Notice GRN No. 791 standards
Price Benchmarks
| Grade | Price Range (USD/kg) | MOQ |
|---|---|---|
| Standard 98% | $120–$850 | 1 kg |
| Premium 99% | $500–$900 | 1 kg |
| Pharmaceutical Grade | $9,200+ (average) | Custom |
Note: Price variations reflect differences in purity, production method, and supplier positioning. The pharmaceutical-grade segment commands premium pricing due to high purity requirements and small-batch, high-value production models.
Quality Assurance & Supply Chain Excellence
Our Commitment
Vertically Integrated Manufacturing: Full control from fermentation to finished powder
Batch-to-Batch Consistency: Verified by in-house HPLC testing
Comprehensive Testing: Third-party laboratory verification for heavy metals, microbial safety, and potency
Full Documentation: Batch-specific CoA, MSDS, Certificate of Origin, stability data
Temperature-Controlled Logistics: Secure global shipping with full export documentation
Supplier Evaluation Criteria for B2B Buyers
| Criterion | What to Look For |
|---|---|
| Manufacturer Type | Direct manufacturer (vs. trader) for better pricing and quality control |
| Certifications | cGMP, ISO 9001, HACCP, FDA-registered facility |
| Testing Capabilities | In-house HPLC, ICP-MS laboratories |
| Purity | ≥98% (HPLC verified) |
| Production Method | Fermentation-based (vs. chemical synthesis) for cleaner product |
| Documentation | Batch-specific CoA, stability data, MSDS |
| Regulatory Status | FDA GRAS compliance documentation |
Storage & Handling Recommendations
Store in tightly sealed containers protected from light and moisture
Maintain temperature at 15–25°C (59–77°F) in a cool, dry environment
Protect from direct sunlight and humidity
Use original packaging; avoid exposure to air for extended periods
Shelf Life: 24 months from date of manufacture in original sealed packaging under proper storage conditions
Why Partner With Us?
1. Technical & Formulation Excellence
Vertically integrated fermentation manufacturing for consistent quality
Multiple purity grades: 98%–99% specifications
Formulation support: Guidance on optimal dosage, blend compatibility, and application-specific challenges
FDA GRAS-compliant production for food and beverage applications
2. Regulatory & Compliance Leadership
FDA GRAS Notice GRN No. 791: Approved for use in protein shakes and beverages
Full documentation: Batch-specific CoA, MSDS, Certificate of Origin, stability data
Third-party testing: Comprehensive quality control
Global compliance: Documentation for FDA, EFSA, and other international regulatory bodies
3. Supply Chain Security
Scalable production capacity: From R&D samples to full container orders
Temperature-controlled logistics: Secure global shipping
Flexible MOQs: Samples (100g–1kg), small production runs (5kg–25kg), full containers (≥500kg)
Reliable delivery schedules: Consistent supply for your manufacturing needs
4. Customer Partnership
Dedicated account management: Responsive service for B2B partners
Private labeling and OEM/ODM services: Custom capsule, tablet, and powder sachet filling
Co-development opportunities: Custom formulations for specific applications
Competitive tiered pricing: Direct manufacturer pricing with volume discounts
Request Samples & Technical Documentation
Elevate your product lines with pharmaceutical-grade urolithin A powder - a scientifically validated, premium bioactive ingredient for the global longevity, sports nutrition, and metabolic health markets. Contact our B2B specialists today to:
✓ Request product samples for R&D evaluation
✓ Receive comprehensive technical dossiers (CoA, MSDS, stability data)
✓ Discuss custom purity specifications (98%–99%)
✓ Obtain competitive bulk pricing based on volume
✓ Schedule a technical consultation for formulation support
Partner with us to deliver science-backed, premium-quality urolithin A solutions to your customers worldwide.
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